Orthopaedics research at Murdoch

The Murdoch Centre for Orthopaedic Research (MCOR), produces high-quality research in the field of orthopaedics, with the aim of discovering innovative ways to improve clinical practice, surgical outcomes and patient experience. Our orthopaedic research focuses on surgical innovation in hip, knee and shoulder surgery and patient rehabilitation following these procedures.

Our research is undertaken at St John of God Murdoch Hospital, one of the leading private hospitals providing orthopaedic care in Western Australia

The PROSPECT Study: A Personalised, Post-operative Cycling Exercise Regimen following Total knee Arthroplasty
This study will evaluate a remotely monitored cycling exercise program following total knee arthroplasty. This new method uses a remotely monitored bicycle power meter in order to prescribe and modify an exercise regimen, tailored specifically to the patient during the weeks following their surgery. In this randomised controlled trial, we will evaluate the short- and long- term outcomes of patients who complete the cycling program compared to those that have completed a non-cycling post-operative program. Results from this study will help inform the acceptability and efficacy of a post-operative cycling exercise program, which is measured and adjusted remotely according to patient feedback and performance.

The Cycle Sprint Test: Assessing Muscle Power and Patient Outcomes Following Knee Arthroplasty
This study examined a new method to measure lower limb muscle power using a bicycle power meter. The first phase of the study examined the reliability of this new test in healthy participants. The second phase of the study examined the post-operative recovery of muscle power and related functional outcomes following total knee replacement. Both studies are now finished and the results published.

The ABSOLUT Global Hip Study: Clinical and radiological outcomes using the Absolut femoral prosthesis and the Global cup system
This study evaluates post-operative radiology and clinical outcomes in patients who undergo primary total hip replacement using the Absolut femoral stem and Global acetabular cup. Patients will be recruited over a two-year period and followed up to 10 years after surgery.

Multi-Center Clinical Evaluation of the ATTUNE® Revision System in the Revision Total Knee Arthroplasty
Five-year, prospective, multi-center, non-randomized, non-controlled study of the ATTUNE® Revision total knee prostheses, utilizing the fixed bearing (FB) and rotating platform (RP) tibial component with the posterior stabilizing (PS) femoral component in revision total knee arthroplasty (TKA).

Multi-Centre Clinical Evaluation of the ATTUNE® Revision System in Complex Primary Total Knee Arthroplasty
Five-year, prospective, multi-centre, non-randomized, non-controlled study of the ATTUNE® Revision total knee prostheses, utilizing the fixed bearing (FB) and rotating platform (RP) tibial component with the posterior stabilizing (PS) femoral component in complex primary total knee arthroplasty (TKA).

KASPAR Study: Outcomes following randomised patellar resurfacing vs retention in anatomically designed total knee arthroplasty
A randomised prospective study, examining patient reported outcome measures in patients who have their patella resurfaced during total knee arthroplasty compared to those who do not have patella resurfacing. Patient outcomes including pain, range of movement, radiology and function is assessed at 4 weeks and 12 months following surgery.

RAISE Study: A Prospective, Multi-center, Randomized Controlled Study to Evaluate the Safety and Efficacy of arthroscopic rotator cuff repair augmented with REGENETEN™ Bioinductive Implant System in Full-thickness rotator cuff tear (large or massive) Repair versus ARCR alone
The study examines tendon healing and patient outcomes in patients requiring full-thickness rotator cuff tear repair or revision repair surgery. Conventional arthroscopic rotator cuff repair surgery is compared to rotator cuff repair augmented with a collagen implant designed to enhance tendon repair and accelerate recovery of function.

RePACT Trial: Does Collagen Scaffold Augmentation of High Grade Partial Rotator Cuff Tendon Tears Improve Early Functional Recovery? A Randomized Controlled Trial
A prospective randomized controlled trial (RCT) that seeks to investigate and compare the post-operative clinical and radiological outcome of either surgical rotator cuff repair (current standard, control arm) versus scaffold augmentation (using the REGENETENTM scaffold, experimental arm) for symptomatic partial thickness rotator cuff tears. Patient outcomes will be collected over a 24-month post-operative period and will include a range of subjective and functional outcomes, radiological measures and patient satisfaction.

OrthoATI for partial thickness cuff tears
This randomised controlled trial evaluates the Perth-developed technology of injecting a patient’s own cultured tendon stem cells into a partial tear of the rotator cuff tendon, with the aim of achieving intrinsic tendon healing without surgery.

OrthoSensor in Reverse Total Shoulder Arthroplasty- a pilot trial
During reverse total shoulder replacement, a novel pressure sensor embedded in the trial joint insert is used to measure joint load prior to implantation of the definitive insert. By correlating intra-operative joint load measurements with post-operative clinical function scores, this study aims to determine the optimal joint load magnitude.

The SPINE Registry
The purpose of this registry is to monitor the long-term outcome of spinal conditions and treatments required. The registry is aiming to improve the management of spinal conditions and how treatments, including surgery, are performed. The registry will allow patient outcomes to be assessed using questionnaires before and after surgery. These will determine how much improvement there has been from a treatment.