Intensive care research at Midland

Our research has contributed significantly to several national and international clinical trials. We are outcome focused with an emphasis on the translation of research, helping to generate knowledge to enhance patient’s health outcomes.

• Epidemiology and determinants of outcomes of hospital acquired blood stream infections in intensive care.
• Efficacy and safety outcomes of drainage of Intensive Care Pleural Effusion (ESSO).
• SPRINT-SARI - Short Period Incidence Study of Severe Acute Respiratory Illness.
• West Australian APRV Ventilation study (WAVES).

Dr Ed Fysh, Consultant General and Respiratory Physician
Dr Ashleigh Drury, Registrar
Dr Manju Rathore, Registrar
Bhaumik Mevavala, ICU

St John of God Midland Public and Private Hospitals

Azzopardi, M., Thomas, R., Muruganandan, S., Lam, C., Garske, A., Kwan, C., Rashid Ali, R., Nguyen, T., Yap, E., Horwood, C., Ritchie, J., Bint, M., Tobin, L., Shrestha, R., Piccolo, F., De Chaneet, C., Creaney, J., Newton, U., Hendrie, D., Murray, K., Read, A., Feller-Kopman, D., Maskell, A., & Lee, C. (2016) Protocol of the Australasian Malignant Pleural Effusion-2 (AMPLE-2) trial: a multicentre randomised study of aggressive versus symptom-guided drainage via indwelling pleural catheters. BMJ Open 6(7):e011480. doi: 10.1136/bmjopen-2016-011480

Chan, K.P., Badlei, A., Tan, C.P., Fitzgerald, D.B., Stanley, C., Fysh, E.T.H., Shrestha, R., Muruganandan, S., Read, C.A., Thomas, R., Lee, Y.G. (2019) Use of indwelling pleural/peritoneal catheter in the management of malignant ascites: a retrospective study of 48 patients. Internal Medicine Journal.

Das, A., Anstey, M., Bass, F., Blythe, D., Buhr, H., Campbell, L., Davda, A., Delaney, A., Gattas, D., Green, C., Ferrier, J., Hammond, N., Palermo, A., Pellicano, S., Phillips, M., Regli, A., Roberts, B., Ross-King, M., Sarode, V., Simpson, S., … Litton, E. (2019). Internet health information use by surrogate decision makers of patients admitted to the intensive care unit: a multicentre survey. Critical care and resuscitation: journal of the Australasian Academy of Critical Care Medicine, 21(4), 305–310. https://pubmed.ncbi.nlm.nih.gov/31778639/

Huseini, T., Manners, D., Jones, S., Piccolo, F. (2019) External validation of the SAPS3-CNIV score to predict hospital mortality following non-invasive ventilations: a retrospective single-centre study. ERJ Open Research. 8, 5. doi:10.1183/23120541.00232-2018

Orde S, Slama M, Stanley N, Huang S, Mclean A. Feasibility of biventricular 3D transthoracic echocardiography in the critically ill and comparison with conventional parameters. Crit Care. 2018;22(1):198. Published 2018 Aug 19. doi.org/10.1186/s13054-018-2133-7

Popowicz, N., Bintcliffe, O., De Fonseka, D., Blyth, G., Smith, A., Piccolo, F., Martin, G., Wong, D., Edey, A., Maskell, N., & Lee, G. (2017) Dose De-escalation of Intrapleural Tissue Plasminogen Activator Therapy for Pleural Infection. The Alteplase Dose Assessment for Pleural Infection Therapy Project. Annals American Thoracic Society 14(6):929-936. doi: 10.1513/AnnalsATS.201609-673OC

Thomas, R., Fysh, E., Smith, A., Lee, P., Kwan, H., Yap, E., Horwood, C., Piccolo, F., Lam, L., Garske, A., Shrestha, R., Kosky, C., Read, A., Murray, K., & Lee, G. (2017) Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients With Malignant Pleural Effusion: The AMPLE Randomized Clinical Trial. Journal of American Medical Association 318(19):1903-1912. doi.org/10.1001/jama.2017.17426