Intensive care research at Subiaco

In addition to contributing to national and international clinical trials, members of the Intensive Care Unit (ICU) Research Group have developed and published multiple studies conceived to address the specific needs of patients admitted to one of the busiest private ICUs in Australia.
  • Over 158,604 patients were admitted to Intensive Care Units in Australia in 2017/2018. 
  • The St John of God Subiaco Hospital ICU is one of the busiest private ICUs in Australia and cares for some of the sickest patients in hospital. St John of God Healthcare Subiaco admitted 1,586 adult patients to the Intensive Care Unit 2018/2019.
  • Our clinical research has the potential for broad benefits, while at the same time, focuses on issues of particular importance to patients treated at our hospital. 
  • Current examples of specific research activity include improving sleep and investigating the effect of admission time to ICU after major surgery. 
 
The focus has been on particular areas of interest and expertise including the use of clinical quality registry data to investigate the processes and outcomes associated with bariatric surgery, delivering the highest quality care to patients undergoing cardiothoracic surgery, support of the next of kin of patients admitted to the ICU, and the importance of sleep in recovery from critical illness.
Consultant Intensivists
A/Professor Kwok Ho

Research Fellow and Consultant

Intensivist
Dr Ed Litton

Head of Department ICU and Consultant Intensivist
Dr David Morgan

Director of Clinical Trials St John of God Healthcare Subiaco and Consultant Intensivist
Professor Steve Webb

Research Officers
Janet Ferrier
Lesley Kemp
Marlene Kolybaba
 
Shehabi, Y., Howe, B., Bellomo, R., Arabi, Y., Bailey, M., Bass, F., Kadiman, S., McArthur, C., Murray, L., Reade, M., Seppelt ,I., Takal, J., Wise, M., Webb, S. Early Sedation with Dexmedetomidine in Critically Ill Patients. NEJM 2019; 380:2506-2517
https://www.nejm.org/doi/full/10.1056/NEJMoa1904710

Shah, A., Sugavanam, A., Reid, J., Palmer, A.J., Dickson, E., Brunskill, S., Doree, C., Oliver, C.M., Acheson, A., Baikady, R.R., Bampoe, S., Litton, E., Stanworth, S. Risk of infection associated with intravenous iron preparations: protocol for updating a systematic review. BMJ Open. 2019 Jun 4;9(6): e024618.
https://doi:10.1136/bmjopen-2018-024618

McCann, M., Stamp, N., Ngui, A., Litton, E.
Cardiac Prehabilitation. J Cardiothorac Vasc Anesth. 2019 Aug;33(8):2255-2265.
https://doi:10.1053/j.jvca.2019.01.023

Litton, E.B.F., Delaney, A., Hillis, G., Jacques, T., McGi_ n, D., McGuinness, S., Playford , H., Reid, C., Solman, N., Tran, L., Yarad, L., ANZICS CTG. Prophylactic intra-aortic balloon counterpulsation in high risk cardiac surgery: The PINBALL Pilot, multicentre, registry-linked, randomised, controlled feasibiliity trial. Heart, Lung & Circulation. 2019; Accepted for publication 15 April 2019.

Litton, E., Lim, J. Iron Metabolism: An Emerging Therapeutic Target in Critical Illness. Critical care. 2019; 23(1):81 https://doi.org/10.1186/s13054-019-2373-1 

Litton, E., Law, T., Stamp, N. Tracheostomy in Patients Requiring Prolonged Mechanical Ventilation After Cardiac Surgery. J Cardiothorac Vasc Anesth. 2019 Jan;33(1):91-92.
https://doi:10.1053/j.jvca.2018.07.014

Litton, E., Law, T. Prophylactic, Postoperative, Noninvasive Ventilation After Thoracoabdominal Surgery. J Cardiothorac Vasc Anesth. 2019.
https://doi.org/10.1053/j.jvca.2019.01.034 

Litton, E., Bass, F., Dickson, C., Hillis, G., Inskip, D., Jacques, T., et al. Prophylactic Intra-Aortic Balloon Counterpulsation in High Risk Cardiac Surgery: The PINBALL Pilot Multicentre, Registry-Linked, Randomised, Controlled Feasibility Trial. Heart Lung Circ. 2019 May 3. pii:S1443-9506(19)30345-2.
https://doi:10.1016/j.hlc.2019.04.006 

Litton, E., Bass, F., Delaney, A., Hillis, G., Marasco, S., McGuinness, S., Myles, P.S., Reid, C.M., Smith, J.A
., PINBALL study investigators and the ANZICS CTG. Corrigendum to Six-Month Outcomes After High-Risk Coronary Artery Bypass Graft Surgery and Preoperative Intra-aortic Balloon Counterpulsation Use: An Inception Cohort Study [Journal of Cardiothoracic and Vascular Anesthesia,Volume 32, Issue 5, October 2018,
Pages 2067-2073]. J Cardiothorac Vasc Anesth. 2019 Aug;33(8):2368.
https://doi:10.1053/j.jvca.2019.02.029

Delaney ,L., Litton, E., Van Haren, F. The e_ ectiveness of noise interventions in the ICU. Curr Opin Anaesthesiol. 2019 Jan 28. 
https://doi:10.1097/ACO.0000000000000708

Cheng, V., Rawlins, M., Chang, T., Fox, E., Dyer, J., Allen, C., Litton, E., Page, M.M., Hoad, K., Roberts, J.A. Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy. Chemotherapy. 2019;64(1):17-21. https://doi:10.1159/000499375